Shaham Laboratory

Publications

Titles link to PDFs. For the most current listing, see PubMed.

Preprints

CED-3 caspase promotes dismantling but not onset of non-apoptotic linker cell death in C. elegans. Yarychkivska, Kutscher, Mamriev, Bido, Keil, Larisch & Shaham. Read
Radial-glia-to-astrocyte trans-differentiation and astrocyte transcriptional convergence are coordinated by CEH-43/DLX in C. elegans. Liu, Bradley, Tang, Kim, Milosevic & Shaham. Read
C. elegans E3 ubiquitin ligase EBAX-1 promotes non-apoptotic linker cell-type death (LCD) through target directed miRNA degradation. Horowitz, Yarychkivska, Lu & Shaham. Read
Astrocyte-derived extracellular matrix proteins regulate synapse remodeling in stress-induced depression. Zhang et al. Read
Non-apoptotic death of the C. elegans linker cell is primed by MYRF-1 activation of pqn-41/polyQ. Yarychkivska et al. 2025. Read

Published work

2026

A molecular timer couples organism-wide temporal identity to developmental checkpoints. Wu, Wang, Pryor, Valentino, Ritter, Loel, Yarychkivska, Shaham, Kinney, Ercan, Joshua-Tor & Hammell. Proc. Natl. Acad. Sci. 123:e2606846123. PDF Supp

2025

Mitochondria transported by Kinesin 3 prevent localized calcium spiking to inhibit caspase-dependent specialized cell death. Sharmin et al. Current Biology 35:4932–4945. PDF Supp
C. elegans LET-381/FoxF and DMD-4/DMRT control development of the mesodermal HMC endothelial cell. Stefanakis, Xi, Jiang & Shaham. Development 152:dev204622. PDF
Glia detect and mount a protective response to loss of dendrite substructure integrity in C. elegans. Varandas et al. Nature Communications 16:79. PDF Supp

2024

Apoptotic and non-apoptotic cell death in C. elegans development. Horowitz & Shaham. Annual Review of Genetics 58:113–134. PDF
C. elegans PPEF-type phosphatase functions in diverse classes of cilia to regulate nematode behaviors. Barbelanne et al. Scientific Reports 14:28347. PDF Supp
Glia development and function in the nervous system of Caenorhabditis elegans. Singhvi, Shaham & Rapti. Cold Spring Harb. Perspect. Biol. 16:a041346. PDF
LET-381/FoxF and its target UNC-30/Pitx2 specify and maintain the molecular identity of C. elegans mesodermal glia that regulate motor behavior. Stefanakis, Jiang, Liang & Shaham. The EMBO Journal. PDF

2023

Nucleus-independent transgenerational small RNA inheritance in Caenorhabditis elegans. Rieger et al. Science Advances 9:eadj8618. PDF Supp
Q&A: Shai Shaham. Shaham. Current Biology 33:R702–R704. PDF

2022

A developmental pathway for epithelial-to-motoneuron transformation in C. elegans. Rashid, Tevlin, Lu & Shaham. Cell Reports 40:111414. PDF Supp
Parental experience regulates sexual attraction for multiple generations. Toker et al. Developmental Cell 57:298–309. PDF

2021

Nuclear hormone receptors promote gut and glia detoxifying-enzyme induction and protect C. elegans from the mold P. brevicompactum. Wallace et al. Cell Reports 37:110166. PDF
Lineage-specific control of convergent differentiation by a Forkhead repressor. Mizeracka et al. Development 148:dev199493. PDF
BLMP-1 promotes developmental cell death in C. elegans by timely repression of ced-9/bcl-2 transcription. Jiang et al. Development 148:dev193995. PDF
Disabling Fanconi anemia signaling in stem cells leads to radioresistance and genomic instability. Deng et al. Cancer Research 81:3706–3716. PDF Supp
Glia actively sculpt sensory neurons by controlled phagocytosis to tune animal behavior. Raiders et al. eLife 10:e63532. PDF
Behaviorally consequential astrocytic regulation of neural circuits. Nagai et al. Neuron 109:576–596. PDF

2020

Stress-induced neural plasticity mediated by glial GPCR REMO-1 promotes C. elegans adaptive behavior. Lee, Procko, Katz & Shaham. Cell Reports 34:108607. PDF
Cell death in animal development. Ghose & Shaham. Development 147:dev191882. PDF
Age-dependent changes in receptive ending shape and activity of a C. elegans thermosensory neuron and thermotaxis behavior. Huang et al. Aging Cell. PDF
Development or disease: caspases balance growth and immunity in C. elegans. Yarychkivska & Shaham. Developmental Cell 53:259–260. PDF

2019

Glia–neuron interactions in Caenorhabditis elegans. Singhvi & Shaham. Annual Review of Neuroscience 42:149–168. PDF
Learning and memory: mind over matter in C. elegans. Katz & Shaham. Current Biology 29:R365–R367. PDF
Glutamate spillover in C. elegans triggers repetitive behavior through presynaptic activation of MGL-2/mGluR5. Katz et al. Nature Communications. PDF Supp

2018

RAB-35 and ARF-6 GTPases mediate engulfment and clearance following linker cell-type death. Kutscher, Keil & Shaham. Developmental Cell 47:222–238. PDF Supp
Automated C. elegans embryo alignments reveal brain neuropil position invariance despite lax cell body placement. Insley & Shaham. PLoS One 13:e0194861. PDF Supp
EFF-1 fusogen promotes phagosome sealing during cell process clearance in Caenorhabditis elegans. Ghose et al. Nature Cell Biology 20:393–399. PDF Supp
Glia modulate a neuronal circuit for locomotion suppression during sleep in C. elegans. Katz et al. Cell Reports 22:2575–2583. PDF Supp

2017

IGDB-2, an Ig/FNIII protein, binds the ion channel LGC-34 and controls sensory compartment morphogenesis in C. elegans. Wang et al. Developmental Biology 430:105–112. PDF Supp
Glia initiate brain assembly through noncanonical Chimaerin–Furin axon guidance in C. elegans. Rapti, Shan, Lu & Shaham. Nature Neuroscience 20:1350–1360. PDF Supp
Sensory cilia: generating diverse shapes one Ig domain at a time. Wallace & Shaham. Current Biology 27:R654–R656. PDF
Non-apoptotic cell death in animal development. Kutscher & Shaham. Cell Death & Differentiation 24:1326–1336. PDF
Infrared laser-induced gene expression for tracking development and function of single C. elegans embryonic neurons. Singhal & Shaham. Nature Communications. PDF Supp
Long-term high-resolution imaging of developing C. elegans larvae with microfluidics. Keil et al. Developmental Cell 40:202–214. PDF Supp

2016

Transcriptional control of non-apoptotic developmental cell death in C. elegans. Malin et al. Cell Death & Differentiation 23:1985–1994. PDF Supp
A high-throughput small molecule screen for C. elegans linker cell death inhibitors. Schwendeman & Shaham. PLoS One 11:e0164595. PDF Supp
A secreted bacterial peptidoglycan hydrolase enhances tolerance to enteric pathogens. Rangan et al. Science 353:1434–1437. PDF Supp
Maintenance and propagation of a deleterious mitochondrial genome by the mitochondrial UPR. Lin et al. Nature 533:416–419. PDF
A glial K/Cl transporter controls neuronal receptive ending shape by chloride inhibition of an rGC. Singhvi et al. Cell 165:936–948. PDF
PROS-1/Prospero is a major regulator of the glia-specific secretome controlling sensory-neuron shape and function in C. elegans. Wallace et al. Cell Reports 15:550–562. PDF Supp

2015

HSF-1 activates the ubiquitin proteasome system to promote non-apoptotic developmental cell death in C. elegans. Kinet et al. eLife. PDF Supp
Cell death in C. elegans development. Malin & Shaham. Current Topics in Developmental Biology 114:1–42. PDF
FBN-1, a fibrillin-related protein, is required for resistance of the epidermis to mechanical deformation during C. elegans embryogenesis. Kelley et al. eLife. PDF Supp
Glial development and function in the nervous system of C. elegans. Shaham. Cold Spring Harb. Perspect. Biol. PDF

2014

Noncanonical cell death in the nematode Caenorhabditis elegans. Kinet & Shaham. Methods in Enzymology 545:157–180. PDF
Forward and reverse mutagenesis in C. elegans. Kutscher & Shaham. WormBook. PDF

2013

Development of neurons and glia: editorial overview. Pfaff & Shaham. Current Opinion in Neurobiology 23:901–902. PDF
Directional locomotion of C. elegans in the absence of external stimuli. Peliti, Chuang & Shaham. PLoS One 8:e78535. PDF Supp
polyQ disease: misfiring of a developmental cell death program? Blum, Schwendeman & Shaham. Trends in Cell Biology 23:168–174. PDF
Related F-box proteins control cell death in C. elegans and human lymphoma. Chiorazzi et al. PNAS 110:3943–3948. PDF
Two novel DEG/ENaC channel subunits expressed in glia are needed for nose-touch sensitivity in Caenorhabditis elegans. Han et al. Journal of Neuroscience 33:936–949. PDF

2012

On the morphogenesis of glial compartments in the sensory organs of Caenorhabditis elegans. Oikonomou & Shaham. Worm 1:50–54. PDF
Sensory organ remodeling in Caenorhabditis elegans requires the zinc-finger protein ZTF-16. Procko, Lu & Shaham. Genetics 190:1405–1415. PDF Supp
Control of non-apoptotic developmental cell death in C. elegans by a polyglutamine-repeat protein. Blum et al. Science 335:970–973. PDF Supp
Some, but not all, retromer components promote morphogenesis of C. elegans sensory compartments. Oikonomou et al. Developmental Biology 362:42–49. PDF Supp

2011

Quick guide: stress. Procko & Shaham. Current Biology 21:R908–R910. PDF
Opposing activities of LIT-1/NLK and DAF-6/Patched-related direct sensory compartment morphogenesis in C. elegans. Oikonomou et al. PLoS Biology 9:e1001121. PDF Supp
A spatial and temporal map of C. elegans gene expression. Spencer et al. Genome Research 21:325–341. PDF Supp
Delivery of tubulin isotypes to sensory cilium middle and distal segments by intraflagellar transport. Hao et al. Nature Cell Biology 13:790–798. PDF
The glia of Caenorhabditis elegans. Oikonomou & Shaham. Glia 59:1253–1263. PDF
Glia delimit shape changes of sensory neuron receptive endings in C. elegans. Procko, Lu & Shaham. Development 138:1371–1381. PDF Supp

2010

Assisted morphogenesis: glial control of dendrite shapes. Procko & Shaham. Current Opinion in Cell Biology 22:560–565. PDF
The microRNA miR-124 controls gene expression in the sensory nervous system of Caenorhabditis elegans. Clark et al. Nucleic Acids Research 38:3780–3793. PDF Supp
Chemosensory organs as models of neuronal synapses. Shaham. Nature Reviews Neuroscience 11:212–217. PDF
Twigs into branches: how a filopodium becomes a dendrite. Heiman & Shaham. Current Opinion in Neurobiology 20:86–91. PDF

2009

Synaptogenesis: new roles for an old player. Procko & Shaham. Current Biology 19:R1114–R1115. PDF
galign: a tool for rapid genome polymorphism discovery. Shaham. PLoS One 4:e7188. PDF
DEX-1 and DYF-7 establish sensory dendrite length by anchoring dendritic tips during cell migration. Heiman & Shaham. Cell 137:344–355. PDF Supp Movies

2008

Glia are essential for sensory organ function in C. elegans. Bacaj, Tevlin, Lu & Shaham. Science 322:744–747. PDF Supp
Ceramide biogenesis is required for radiation-induced apoptosis in the germ line of Caenorhabditis elegans. Deng et al. Science 322:110–115. PDF
A glial DEG/ENaC channel functions with neuronal channel DEG-1 to mediate specific sensory functions in C. elegans. Wang et al. The EMBO Journal 27:2388–2399. PDF Supp
Non-canonical cell death programs in the nematode Caenorhabditis elegans. Blum, Driscoll & Shaham. Cell Death & Differentiation 15:1124–1131. PDF
mls-2 and vab-3 control glia development, hlh-17/Olig expression, and glia-dependent neurite extension in C. elegans. Yoshimura et al. Development 135:2263–2275. PDF Supp
Sensory signaling-dependent remodeling of olfactory cilia architecture in C. elegans. Mukhopadhyay et al. Developmental Cell 14:762–774. PDF
The conserved proteins CHE-12 and DYF-11 are required for sensory cilium function in Caenorhabditis elegans. Bacaj, Lu & Shaham. Genetics 178:989–1002. PDF

2007

Counting mutagenized genomes and optimizing genetic screens in Caenorhabditis elegans. Shaham. PLoS One 2:e1117. PDF
Necrosis and the serpin under't. Abraham & Shaham. Developmental Cell 13:464–465. PDF
Ancestral roles of glia suggested by the nervous system of Caenorhabditis elegans. Heiman & Shaham. Neuron Glia Biology 3:55–61. PDF
Distinct IFT mechanisms contribute to the generation of ciliary structural diversity in C. elegans. Mukhopadhyay et al. The EMBO Journal 26:2966–2980. PDF
Temporal control of cell-specific transgene expression in C. elegans. Bacaj & Shaham. Genetics 176:2651–2655. PDF
Timing of developmental cell death onset controlled by transcriptional induction of the C. elegans ced-3 caspase-encoding gene. Maurer, Chiorazzi & Shaham. Development 134:1357–1368. PDF Supp
A morphologically conserved non-apoptotic program promotes linker cell death in C. elegans. Abraham, Lu & Shaham. Developmental Cell 12:73–86. PDF Supp

2006

Glia–neuron interactions in the nervous system of C. elegans. Shaham. Current Opinion in Neurobiology 16:522–528. PDF
Worming into the cell: viral reproduction in C. elegans. Shaham. PNAS 103:3955–3956. PDF
The dynami(n)cs of cell corpse engulfment. Shaham. Developmental Cell 10:690–691. PDF

2005

Glia–neuron interactions in nervous system function and development. Shaham. Current Topics in Developmental Biology 69:39–66. PDF
C. elegans daf-6 encodes a Patched-related protein required for lumen formation. Perens & Shaham. Developmental Cell 8:893–906. PDF Supp
Functional genomics of the cilium, a sensory organ. Blacque et al. Current Biology 15:935–941. PDF
C. elegans ced-13 can promote apoptosis and is induced in response to DNA damage. Schumacher et al. Cell Death & Differentiation 12:153–161. PDF Supp

2004

Death without caspases, caspases without death. Abraham & Shaham. Trends in Cell Biology 14:184–193. PDF

2003

Apoptosis: a process with a NAC for complexity. Shaham. Cell 114:659–661. PDF

2002

Control of neuronal subtype identity by the C. elegans ARID protein CFI-1. Shaham & Bargmann. Genes & Development 16:972–983. PDF

1999

Mutational analysis of the C. elegans cell death gene ced-3. Shaham, Reddien, Davies & Horvitz. Genetics 153:1655–1671. PDF
Nuclear export of Far1p in response to pheromones requires the export receptor Msn5p/Ste21p. Blondel et al. Genes & Development 13:2286–2300. PDF

1998

Identification of multiple Caenorhabditis elegans caspases and their potential roles in proteolytic cascades. Shaham. Journal of Biological Chemistry 273:35109–35117. PDF
Death-defying yeast identify novel apoptosis genes. Shaham, Shuman & Herskowitz. Cell 92:425–427. PDF

1996

An alternatively spliced C. elegans ced-4 RNA encodes a novel cell-death inhibitor. Shaham & Horvitz. Cell 86:201–208. PDF
The C. elegans cell-death protein CED-3 is a cysteine protease with substrate specificities similar to those of the human CPP32 protease. Xue, Shaham & Horvitz. Genes & Development 10:1073–1083. PDF
Developing C. elegans neurons may contain both cell-death protective and killer activities. Shaham & Horvitz. Genes & Development 10:578–591. PDF

1994

The genetics of programmed cell death in the nematode Caenorhabditis elegans. Horvitz, Shaham & Hengartner. Cold Spring Harbor Symp. Quant. Biol. 59:377–385. PDF

1993

The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1-beta converting enzyme. Yuan, Shaham, Ledoux, Ellis & Horvitz. Cell 75:641–652. PDF